AR (Androgen Receptor)

Catalog #	Size	Price(US$)
X30179	5,000 units (ng)	$357.5
X30179	12,500 units (ng)	$713.9

Species	Express Host/Source	Molecular Weight
Human	Baculovirus	101 kDa

Product Name	AR (Androgen Receptor)
Category Group	Nuclear Hormone Receptors
Synonyms	AIS; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM.
Product Description	This Flag tagged recombinant AR is expressed in baculovirus system and purified by an affinity chromatography in combination with FPLC chromatography.
Tag	Flag tag
Activity	1 unit equals 1 nanogram of purified protein
Purity on SDS-PAGE	95
Applications	Research Use only and not for Drug or Diagnostic purposes. AR can be used for gel mobility shift assay, for protein-protein and small molecules-protein interactions assay.
Formulation	20 mM Tris-Cl (pH 8.0), 20% Glycerol, 100 mM KCl, 0.2 mM EDTA and 1 mM DTT
Accession #	NM_000044
Backgound	The AR, androgen receptor is an androgen-activated member of the nuclear receptor superfamily of transcription factors. Signaling by the androgen receptor plays a key role in proper development and function of male reproductive organs. The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. The androgen receptor (AR) has been shown to play a critical role in the development and progression of the prostate cancer.
References	Marques,R.B., et al., Int. J. Cancer 117 (2), 221-229 (2005) Metzger,E., et al., Nature 437 (7057), 436-439 (2005) Murthy,S., et al., Prostate 64 (4), 362-372 (2005 Hillmer,A.M., et al., Am. J. Hum. Genet. 77 (1), 140-148 (2005) Gao,S., et al., Mol. Endocrinol. 19 (7), 1792-1802 (2005)